Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in ulcerative colitis.

Nature communications - 28 Apr 2022

Brooks-Warburton Johanne, Modos Dezso, Sudhakar Padhmanand, Madgwick Matthew, Thomas John P, Bohar Balazs, Fazekas David, Zoufir Azedine, Kapuy Orsolya, Szalay-Beko Mate, Verstockt Bram, Hall Lindsay J, Watson Alastair, Tremelling Mark, Parkes Miles, Vermeire Severine, Bender Andreas, Carding Simon R, Korcsmaros Tamas

Abstract excerpt

We describe a precision medicine workflow, the integrated single nucleotide polymorphism network platform (iSNP), designed to determine the mechanisms by which SNPs affect cellular regulatory networks, and how SNP co-occurrences contribute to disease pathogenesis in ulcerative colitis (UC). Using SNP profiles of 378 UC patients we map the regulatory effects of the SNPs to a human signalling network containing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Karyopherins

Share to MicroRNAs

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 35484353
DOI: 10.1038/s41467-022-29998-8
PMCID: PMC9051123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in ulcerative colitis.PMID 35484353Read ↗

A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in a complex diseaseSemantic proximity Read ↗

Epithelial regulatory networks link non-coding genetic variation to clinical heterogeneity in ulcerative colitisSemantic proximity Read ↗

Pathway specific polygenic risk scores identify pathways and patient clusters associated with inflammatory bowel disease risk, severity and treatment responseSemantic proximity Read ↗

Systematic post-translational modification profiling identifies molecular subtypes and therapeutic targets in ulcerative colitis: evidence from multi-omics integrationSemantic proximity Read ↗

SNPnotes: high-throughput tissue-specific functional annotation of single nucleotide variantsSemantic proximity Read ↗

Patient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis.Semantic proximity Read ↗

Pathway Analysis Incorporating Protein-Protein Interaction Networks Identified Candidate Pathways for the Seven Common Diseases.Semantic proximity Read ↗

Decoding non-coding SNPs: systems genomics modelling dissects the heterogeneity of IBD.Semantic proximity Read ↗

Decoding Non-coding SNPs: Systems Genomics Modelling Dissects the Heterogeneity of IBDSemantic proximity Read ↗

Long-range regulatory target prediction reveals shared genetic background across ulcerative colitis, Crohn’s disease, primary sclerosing cholangitis and ankylosing spondylitisSemantic proximity Read ↗

Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms.Semantic proximity Read ↗

An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.