Article

In silico degradomics reveals disease- and endotype-specific alterations in the joint tissue landscape

2026-02-19

Abstract excerpt

Tissues dynamically remodel extracellular matrix to maintain homeostasis, alterations in which are an early pathogenic hallmark of disease. Protein degradation, essential for tissue remodelling, is often dismissed as indiscriminate damage, despite evidence of its specificity. A major determinant of protein tissue levels and activity, matrix proteolysis also creates circulating degradation products that are emergin...

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Literature Corpus work: 3b1e657e-2a5b-5374-ac55-7632bb8727d2
DOI: 10.64898/2026.02.18.706378

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