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Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney

10 Jul 2023

Abstract excerpt

During ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are...

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PMID: 37437747
DOI: 10.1016/j.matbio.2023.07.001

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