Article

Integrated forward and reverse degradomics uncovers the proteolytic landscape of aortic aneurysms and the roles of MMP9 and mast cell chymase

2024-06-27

Abstract excerpt

<h4>Background</h4> Dysregulated proteolysis is implicated in thoracic (TAA) and abdominal aortic aneurysm (AAA) pathogenesis, but the proteolytic landscapes (degradomes) of aneurysmal and normal aorta, and contributions of individual proteases remain undefined. Here, a proteome-wide approach was used to uncover TAA and AAA degradomes, compare them quantitatively and define the specific role in aortic remodeling...

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Literature Corpus work: 09594a79-aa51-574c-8f1c-e2c4b6eed894
DOI: 10.1101/2024.06.26.600914

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