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Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of <i>POLB</i>

2025-04-09

Abstract excerpt

We measured genomic responses to active vitamin D, 1α,25-dihydroxyvitamin D (1,25D), in colonic organoids from individuals of African and European ancestry. Given protective effects of 1,25D for gastrointestinal conditions such as colorectal cancer, organoid cultures enabled evaluation of condition-specific responses in relevant target tissue. We found significant alterations in transcriptional and chromatin acces...

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Literature Corpus work
3b07733c-3494-598f-a354-3312c6664f6e
DOI
10.1101/2025.04.09.647365
Open publication

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Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of <i>POLB</i>DOI 10.1101/2025.04.09.647365
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