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Article

Colonic transcriptional response to 1α,25(OH)2 vitamin D3 in African- and European-Americans.

The Journal of steroid biochemistry and molecular biology - 1 Apr 2017

Alleyne Dereck, Witonsky David B, Mapes Brandon, Nakagome Shigeki, Sommars Meredith, Hong Ellie, Muckala Katy A, Di Rienzo Anna, Kupfer Sonia S

Abstract excerpt

Colorectal cancer (CRC) is a significant health burden especially among African Americans (AA). Epidemiological studies have correlated low serum vitamin D with CRC risk, and, while hypovitaminosis D is more common and more severe in AA, the mechanisms by which vitamin D modulates CRC risk and how these differ by race are not well understood. Active vitamin D (1α,25(OH)2D3) has chemoprotective effects primarily...

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Source

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Identifiers

PMID: 28163244
DOI: 10.1016/j.jsbmb.2017.02.001
PMCID: PMC5642973

Genes

ZSWIM4
HDAC3
UPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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