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Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex

6 Jun 2022

Abstract excerpt

Observational studies indicate that calcium supplementation may protect against colorectal cancer. Stratified analyses suggest that this protective effect may differ based on anatomic subsite and sex, but these hypotheses have been difficult to test experimentally. Here, we exposed 36 patient-derived organoid lines derived from normal colon biopsies (21 right colons, 15 left colons) of unrelated subjects (18...

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PMID: 36095330
DOI: 10.1158/1940-6207.capr-22-0068

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