Article

Microvasculopathy And Soft Tissue Calcification In Mice Are Governed by Fetuin-A, Pyrophosphate And Magnesium

2019-03-14

Abstract excerpt

<h4>Objective</h4> Calcifications can disrupt organ function in the cardiovascular system and the kidney, and are particularly common in patients with chronic kidney disease (CKD). Fetuin-A deficient mice maintained against the genetic background DBA/2 exhibit particularly severe soft tissue calcifications, while fetuin-A deficient C57BL/6 mice remain healthy. We employed molecular genetic analysis to identify ri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3afbb9ac-eafd-5a96-bdb9-78313175503a
DOI: 10.1101/577239

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microvasculopathy And Soft Tissue Calcification In Mice Are Governed by Fetuin-A, Pyrophosphate And MagnesiumDOI 10.1101/577239Read

Microvasculopathy, Luminal Calcification and Premature Aging in Fetuin-A Deficient MiceSemantic proximity Read

Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice.Semantic proximity Read

High-dose oral pyrophosphate inhibits connective tissue calcification in Abcc6 null mice but affects bone structureSemantic proximity Read

The molecular and physiological roles of ABCC6: more than meets the eyeSemantic proximity Read

Pyrophosphate deficiency in vascular calcification.Semantic proximity Read

Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice.Semantic proximity Read

The molecular biology and pathophysiology of vascular calcification.Semantic proximity Read

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.Semantic proximity Read

Animal models with pathological mineralization phenotypes.Semantic proximity Read

Vascular calcification in chronic kidney disease associated with pathogenic variants in ABCC6.Semantic proximity Read

Disruption of Abcc6 Transporter in Zebrafish Causes Ocular Calcification and Cardiac Fibrosis.Semantic proximity Read

Fetuin-A protects against atherosclerotic calcification in CKD.Semantic proximity Read