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Article

Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice.

The American journal of pathology - 1 Jun 2017

Pomozi Viola, Brampton Christopher, van de Wetering Koen, Zoll Janna, Calio Bianca, Pham Kevin, Owens Jesse B, Marh Joel, Moisyadi Stefan, Váradi András, Martin Ludovic, Bauer Carolin, Erdmann Jeanette, Aherrahrou Zouhair, Le Saux Olivier

Abstract excerpt

Soft tissue calcification occurs in several common acquired pathologies, such as diabetes and hypercholesterolemia, or can result from genetic disorders. ABCC6, a transmembrane transporter primarily expressed in liver and kidneys, initiates a molecular pathway inhibiting ectopic calcification. ABCC6 facilitates the cellular efflux of ATP, which is rapidly converted into pyrophosphate (PPi), a major calcification...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28416300
DOI: 10.1016/j.ajpath.2017.02.009
PMCID: PMC5455066

Genes

ABCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice.PMID 28416300Read ↗

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