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Article

Disruption of Abcc6 Transporter in Zebrafish Causes Ocular Calcification and Cardiac Fibrosis.

International journal of molecular sciences - 29 Dec 2020

Sun Jianjian, She Peilu, Liu Xu, Gao Bangjun, Jin Daqin, Zhong Tao P

Abstract excerpt

Pseudoxanthoma elasticum (PXE), caused by ABCC6/MRP6 mutation, is a heritable multisystem disorder in humans. The progressive clinical manifestations of PXE are accompanied by ectopic mineralization in various connective tissues. However, the pathomechanisms underlying the PXE multisystem disorder remains obscure, and effective treatment is currently available. In this study, we generated zebrafish abcc6a mutants...

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Identifiers

PMID: 33383974
DOI: 10.3390/ijms22010278
PMCID: PMC7795442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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