Article

High-dose oral pyrophosphate inhibits connective tissue calcification in Abcc6 null mice but affects bone structure

2025-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Pseudoxanthoma elasticum is a rare inherited disorder marked by abnormal calcium phosphate deposition in soft connective tissues, particularly the skin, arteries, and eyes. It is caused by inactivating mutations in the ABCC6 gene, which encodes a hepatic efflux transporter. Loss of ABCC6 function leads to reduced plasma levels of pyrophosphate, a key inhibitor of calcification, thereby promotin...

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Literature Corpus work: f0fa278c-85c7-57ef-8451-8c9614205a6d
DOI: 10.1101/2025.07.16.665176

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