Article

Conditional KCa3.1-Transgene Induction in Murine Skin Produces Pruritic Eczematous Dermatitis With Severe Epidermal Hyperplasia and Hyperkeratosis

2019-09-05

Abstract excerpt

<h4>ABSTRACT</h4> Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences of genetically encoded induction of the cell volume-regulating Ca 2+ -activated KCa3.1 channel ( Kcnn4 ) for murine epidermal homeostasis. Doxycycline-treated mice harboring the KCa3.1+-transgene under the control of the reverse tetracycline-sensitive transactivator (rtTA)...

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Literature Corpus work: 3af2d6e3-f681-5250-abad-e43fc7a1c45b
DOI: 10.1101/759274

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