Article

IKK2 controls the inflammatory potential of tissue-resident regulatory T cells

2023-10-18

Abstract excerpt

<title>Abstract</title> <p>Loss-of-function mutations have provided crucial insights into the immunoregulatory actions of Foxp3 + regulatory T cells (Tregs). By contrast, we know very little about the consequences of defects that amplify aspects of Treg function or differentiation. We report that mice heterozygous for an <italic>Ikbkb</italic> gain-of-function (GoF) mutation develop psoriasis. Doubling the gene d...

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Literature Corpus work: 9518b5d1-a769-5cbd-a3f1-1c91835caefb
DOI: 10.21203/rs.3.rs-2933300/v1

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