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Article

Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation.

The Journal of clinical investigation - 1 Jun 2011

Fujioka Masato, Tokano Hisashi, Fujioka Keiko Shiina, Okano Hideyuki, Edge Albert S B

Abstract excerpt

Most degenerative diseases begin with a gradual loss of specific cell types before reaching a threshold for symptomatic onset. However, the endogenous regenerative capacities of different tissues are difficult to study, because of the limitations of models for early stages of cell loss. Therefore, we generated a transgenic mouse line (Mos-iCsp3) in which a lox-mismatched Cre/lox cassette can be activated to...

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Identifiers

PMID: 21576819
DOI: 10.1172/JCI45081
PMCID: PMC3104751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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