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Article

Cytokine induced 3‐D organotypic psoriasis skin model demonstrates distinct roles for NF‐κB and JAK pathways in disease pathophysiology

25 Feb 2022

Abstract excerpt

Psoriasis vulgaris is an inflammatory skin disease that affects 2%-3% of the population worldwide. One of the major challenges in discovering novel therapies is the poor translatability of animal models to human disease. Therefore, it is imperative to develop human preclinical models of psoriasis that are amenable to pharmacological intervention. Here, we report a 3-D reconstituted human epidermis (RHE) culture...

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Cytokine Signaling Pathways and Interactions
Dermatology and Skin Diseases
Psoriasis: Treatment and Pathogenesis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35213752
DOI: 10.1111/exd.14551

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