Article
Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling.
The Journal of investigative dermatology - 1 Mar 2009
Zheng Tao, Oh Min H, Oh Sun Y, Schroeder John T, Glick Adam B, Zhu Zhou
Abstract excerpt
IL-13 has been implicated in the pathogenesis of allergic diseases, including atopic dermatitis (AD). However, a direct role of IL-13 in AD has not been established. We aimed to develop an inducible transgenic model in which IL-13 can be expressed in the skin and to define the resulting dermal phenotype and mechanisms involved. The keratin 5 promoter was used with a tetracycline-inducible system to target IL-13...
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