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Article

Effect of Bile Acid Sequestrants on the Risk of Cardiovascular Events: A Mendelian Randomization Analysis.

Circulation. Cardiovascular genetics - 1 Aug 2015

Ross Stephanie, D'Mello Matthew, Anand Sonia S, Eikelboom John, Stewart Alexandre F R, Samani Nilesh J, Roberts Robert, Paré Guillaume

Abstract excerpt

BACKGROUND: Statins lower low-density lipoprotein cholesterol (LDL-C) and risk of coronary artery disease (CAD), but they may be ineffective or not tolerated. Bile acid sequestrants (BAS) reduce LDL-C, yet their clinical efficacy on CAD remains controversial. METHODS AND RESULTS: We conducted a systematic review and meta-analysis of randomized controlled trials to assess the effect of cholestyramine and...

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Source

Identifiers

PMID: 26043746
DOI: 10.1161/CIRCGENETICS.114.000952

Genes

CAD
ABCG5
ABCG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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