Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice

Abstract excerpt

The emerging field of regenerative cell therapy is still limited by the few cell types that can reliably be differentiated from pluripotent stem cells and by the immune hurdle of commercially scalable allogeneic cell therapeutics. Here, we show that gene-edited, immune-evasive cell grafts can survive and successfully treat diseases in immunocompetent, fully allogeneic recipients. Transplanted endothelial cells...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mechanical Circulatory Support Devices
• Share to Pluripotent Stem Cells Research
• Share to Tissue Engineering and Regenerative Medicine