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Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism†

12 May 2021

Abstract excerpt

One in 54 children in the United States is diagnosed with autism spectrum disorder. De novo germline and somatic mutations cannot account for all cases of autism spectrum disorder, suggesting that epigenetic alterations triggered by environmental exposures may be responsible for a subset of autism spectrum disorder cases. Human and animal studies have shown that exposure of the developing brain to general...

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PMID: 33982067
DOI: 10.1093/biolre/ioab097

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