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Sex‐Specific Behavioral Features of Juvenile and Adult Haploinsufficient Scn2a +/− Female Mice, Model of Autism Spectrum Disorder

31 Aug 2025

Abstract excerpt

ABSTRACT Genetic variants of the SCN2A gene, encoding the Na V 1.2 sodium channel, cause a spectrum of neurodevelopmental and epileptic disorders, and are among those that show the strongest association with Autism Spectrum Disorder (ASD). ASD has a male‐bias prevalence, but several studies have proposed that female prevalence may be underestimated due to different symptomatic expression compared with males....

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PMID: 40887751
DOI: 10.1111/gbb.70034

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