Article

Dysregulation of The Chromatin Environment Leads to Differential Alternative Splicing as A Mechanism Of Disease In a Human Model of Autism Spectrum Disorders

2022-09-09

Abstract excerpt

<h4>ABSTRACT</h4> Autism spectrum disorder (ASD) affects 1 in 44 children. Chromatin regulatory proteins are overrepresented among genes that contain high risk variants in ASD. Disruption of the chromatin environment leads to widespread dysregulation of gene expression, which is traditionally thought as a mechanism of disease pathogenesis associated with ASD. Alternatively, alterations in chromatin dynamics could...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 935ff750-eedb-52bf-a793-2a21a3ef07aa
DOI: 10.1101/2022.09.08.507162

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of The Chromatin Environment Leads to Differential Alternative Splicing as A Mechanism Of Disease In a Human Model of Autism Spectrum DisordersDOI 10.1101/2022.09.08.507162Read

Identification of a transcriptional signature found in multiple models of ASD and related disordersSemantic proximity Read

Maintenance of Heterochromatin links Chromatin Modifiers and Neurodevelopment in Autism Spectrum DisorderSemantic proximity Read

Missense Mutation ADNP p.C687R Disrupts Chromatin Regulation and GABAergic Differentiation in HVDASSemantic proximity Read

Merging data from genetic and epigenetic approaches to better understand autistic spectrum disorder.Semantic proximity Read

Combined analysis of exome sequencing points toward a major role for transcription regulation during brain development in autism.Semantic proximity Read

Alternative splicing in autism spectrum disorder: Recent insights from mechanisms to therapySemantic proximity Read

Targeting epigenetic dysregulation in autism spectrum disorders.Semantic proximity Read

The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal developmentSemantic proximity Read

Multiple genes <i>in cis</i> mediate the effects of a single chromatin accessibility variant on aberrant synaptic development and function in human neuronsSemantic proximity Read

Enhancer-driven gene regulatory network of forebrain human development provides insights into autismSemantic proximity Read

Role of Epigenetics in Drug-Induced Autism Spectrum DisorderSemantic proximity Read

Histone H1 Variants Regulate Neurodevelopmental Transcriptional Programs in Autism with 16p11.2 deletionSemantic proximity Read