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Article

Interplay between maternal Slc6a4 mutation and prenatal stress: a possible mechanism for autistic behavior development.

Scientific reports - 18 Aug 2017

Sjaarda Calvin P, Hecht Patrick, McNaughton Amy J M, Zhou Audrina, Hudson Melissa L, Will Matt J, Smith Garth, Ayub Muhammad, Liang Ping, Chen Nansheng, Beversdorf David, Liu Xudong

Abstract excerpt

The low activity allele of the maternal polymorphism, 5HTTLPR, in the serotonin transporter, SLC6A4, coupled with prenatal stress is reported to increase the risk for children to develop autism spectrum disorder (ASD). Similarly, maternal Slc6a4 knock-out and prenatal stress in rodents results in offspring demonstrating ASD-like characteristics. The present study uses an integrative genomics approach to explore...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28821725
DOI: 10.1038/s41598-017-07405-3
PMCID: PMC5562880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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