Article
Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype.
Nature communications - 7 Aug 2024
Symeonides Christos, Vacy Kristina, Thomson Sarah, Tanner Sam, Chua Hui Kheng, Dixit Shilpi, Mansell Toby, O'Hely Martin, Novakovic Boris, Herbstman Julie B, Wang Shuang, Guo Jia, Chia Jessalynn, Tran Nhi Thao, Hwang Sang Eun, Britt Kara, Chen Feng, Kim Tae Hwan, Reid Christopher A, El-Bitar Anthony, Bernasochi Gabriel B, Delbridge Lea M Durham, Harley Vincent R, Yap Yann W, Dewey Deborah, Love Chloe J, Burgner David, Tang Mimi L K, Sly Peter D, Saffery Richard, Mueller Jochen F, Rinehart Nicole, Tonge Bruce, Vuillermin Peter, Ponsonby Anne-Louise, Boon Wah Chin
Abstract excerpt
Male sex, early life chemical exposure and the brain aromatase enzyme have been implicated in autism spectrum disorder (ASD). In the Barwon Infant Study birth cohort (n = 1074), higher prenatal maternal bisphenol A (BPA) levels are associated with higher ASD symptoms at age 2 and diagnosis at age 9 only in males with low aromatase genetic pathway activity scores. Higher prenatal BPA levels are predictive of...
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