Article

Synthetic single domain antibodies for the conformational trapping of membrane proteins

2017-07-26

Abstract excerpt

<h4>ABSTRACT</h4> Single domain antibodies called nanobodies are excellent affinity reagents for membrane proteins. However, their generation relies on immunizations, which is only amenable to robust proteins and impedes selections in the presence of non-covalent or toxic ligands. To overcome these key limitations, we developed a novel in vitro selection platform, which builds on synthetic nanobodies called sybo...

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Literature Corpus work: 284b87d2-a13b-5e8a-9c89-0023c1985b09
DOI: 10.1101/168559

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