Article

PVN CRF/CRF-R1 signaling links stress to bowel dysfunction, anxiety-like behavior, and colonic barrier injury and is modulated by electroacupuncture in IBS-D-like mice

2026-07-20

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Diarrhea-predominant irritable bowel syndrome (IBS-D) is frequently accompanied by anxiety and intestinal barrier dysfunction, yet the central mechanisms linking stress-related neural signaling to peripheral colonic injury remain incompletely understood. <bold>Aims</bold> To investigate whether paraventricular hypothalamic nucleus (PVN) CRF/CRF-R1 signaling...

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Literature Corpus work: 3ab460b3-2e7a-556c-8b6c-4aaf4209ebaf
DOI: 10.21203/rs.3.rs-10159491/v1

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PVN CRF/CRF-R1 signaling links stress to bowel dysfunction, anxiety-like behavior, and colonic barrier injury and is modulated by electroacupuncture in IBS-D-like miceDOI 10.21203/rs.3.rs-10159491/v1Read

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