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Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce <i>Pseudomonas aeruginosa</i> burden in mice

2024-04-12

Abstract excerpt

Pseudomonas aeruginosa (PA) is an opportunistic, frequently multidrug-resistant pathogen that can cause severe infections in hospitalized patients. Antibodies against the PA virulence factor, PcrV, protect from death and disease in a variety of animal models. However, clinical trials of PcrV-binding antibody-based products have thus far failed to demonstrate benefit. Prior candidates were derivations of antibodies...

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Literature Corpus work
3ab18459-d8c9-5263-8828-1ce26889b794
DOI
10.1101/2024.04.08.588618
Open publication

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Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce <i>Pseudomonas aeruginosa</i> burden in miceDOI 10.1101/2024.04.08.588618
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