Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening.

doi:10.1084/jem.20120033

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Article

Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening.

The Journal of experimental medicine - 2 Jul 2012

DiGiandomenico Antonio, Warrener Paul, Hamilton Melissa, Guillard Sandrine, Ravn Peter, Minter Ralph, Camara Maria Margarita, Venkatraman Vignesh, Macgill Randall S, Lin Jia, Wang Qun, Keller Ashley Elaine, Bonnell Jessica C, Tomich Mladen, Jermutus Lutz, McCarthy Michael P, Melnick David A, Suzich Joann A, Stover C Kendall

Abstract excerpt

Pseudomonas aeruginosa is a leading cause of hospital-associated infections in the seriously ill, and the primary agent of chronic lung infections in cystic fibrosis patients. A major obstacle to effective control of P. aeruginosa infections is its intrinsic resistance to most antibiotic classes, which results from chromosomally encoded drug-efflux systems and multiple acquired resistance mechanisms selected by...

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PMID: 22734046
DOI: 10.1084/jem.20120033
PMCID: PMC3405507

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