Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction

30 May 2025

Abstract excerpt

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), a leading cause of death by an infectious disease globally, has no efficacious vaccine. Antibodies are implicated in M. tuberculosis control, but the mechanisms of action remain poorly understood. We assembled a library of monoclonal antibodies (mAb) and screened for M. tuberculosis-restrictive activity in mice, identifying protective...

Topics

Join the communities discussing this publication.

Monoclonal and Polyclonal Antibodies Research
Mycobacterium research and diagnosis
Tuberculosis Research and Epidemiology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40449485
DOI: 10.1016/j.immuni.2025.05.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restrictionPMID 40449485Read ↗

Antibody-Fab and -Fc features promote <i>Mycobacterium tuberculosis</i> restrictionSemantic proximity Read ↗

Fc-engineered antibodies leverage neutrophils to drive control of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Antigen specificity shapes antibody functions in tuberculosisSemantic proximity Read ↗

Antibody Fc: Linking Adaptive and Innate ImmunitySemantic proximity Read ↗

Immune endotypes in tuberculosis: Keys to decoding disease complexity.Semantic proximity Read ↗

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles.Semantic proximity Read ↗

Lung Resident T Cells Across the Spectrum of TB Infection and DiseaseSemantic proximity Read ↗

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and putative functional rolesSemantic proximity Read ↗

Manipulation and Exploitation Of Host Immune System by Pathogenic Mycobacterium Tuberculosis for its AdvantageSemantic proximity Read ↗

High-throughput single-cell analysis reveals fully human Omp38-specific monoclonal antibodies against Acinetobacter baumanniiSemantic proximity Read ↗

Dynamic antibody responses to the <i>Mycobacterium tuberculosis</i> proteomeSemantic proximity Read ↗

Human memory CD4 <sup>+</sup> T-cells recognize <i>Mycobacterium tuberculosis</i> -infected macrophages amid broader pathogen-specific responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.