Article

Antibody-Fab and -Fc features promote <i>Mycobacterium tuberculosis</i> restriction

2024-10-11

Abstract excerpt

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a leading cause of death by an infectious disease globally, with no efficacious vaccine. Antibodies are implicated in Mtb control, but the mechanisms of antibody action remain poorly understood. We assembled a library of TB monoclonal antibodies (mAb) and screened for the ability to restrict Mtb in mice, identifying protective antibod...

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Literature Corpus work: 3d10381b-1907-5f69-ba5d-bd9085c30846
DOI: 10.1101/2024.10.07.617070

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