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Article

Antibodies against In Vivo-Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomallei.

Infection and immunity - 1 Aug 2017

Zimmerman Shawn M, Dyke Jeremy S, Jelesijevic Tomislav P, Michel Frank, Lafontaine Eric R, Hogan Robert J

Abstract excerpt

Burkholderia mallei, a facultative intracellular bacterium and tier 1 biothreat, causes the fatal zoonotic disease glanders. The organism possesses multiple genes encoding autotransporter proteins, which represent important virulence factors and targets for developing countermeasures in pathogenic Gram-negative bacteria. In the present study, we investigated one of these autotransporters, BatA, and demonstrate...

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Identifiers

PMID: 28507073
DOI: 10.1128/IAI.00102-17
PMCID: PMC5520430

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Antibodies against In Vivo-Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomallei.PMID 28507073Read ↗

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