Article
Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil.
PloS one - 1 Jan 2020
Rodrigues Juliana Carla Gomes, Souza Tatiane Piedade de, Pastana Lucas Favacho, Ribeiro Dos Santos André Maurício, Fernandes Marianne Rodrigues, Pinto Pablo, Wanderley Alayde Vieira, Souza Sandro José de, Kroll José Eduardo, Pereira Adenilson Leão, Magalhães Leandro, Mercês Laís Reis das, Vidal Amanda Ferreira, Vinasco-Sandoval Tatiana, Cavalcante Giovanna Chaves, Guerreiro João Farias, Assumpção Paulo Pimentel de, Ribeiro-Dos-Santos Ândrea, Santos Sidney, Santos Ney Pereira Carneiro Dos
Abstract excerpt
INTRODUCTION: The nudix hydrolase 15 (NUDT15) gene acts in the metabolism of thiopurine, by catabolizing its active metabolite thioguanosine triphosphate into its inactivated form, thioguanosine monophosphate. The frequency of alternative NUDT15 alleles, in particular those that cause a drastic loss of gene function, varies widely among geographically distinct populations. In the general population of northern...
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