Article
Genetic profiling of NUDT15 in the Slovenian population.
Pharmacogenomics - 1 Jan 2024
Šmid Alenka, Urbančič Dunja, Žlajpah Jaka Vrevc, Stollarova Natalia, Prelog Tomaž, Kavčič Marko, Jazbec Janez, Mlinarič-Raščan Irena, Kuželički Nataša Karas
Abstract excerpt
Determining variant TPMT alleles to predict patient response to thiopurine therapy represents one of the first successful implementations of pharmacogenomics in clinical practice. However, despite the TPMT-adjusted thiopurine dosing, some TPMT wild-type patients still exhibit toxicity at standard doses. Over the past decade, the pharmacogene NUDT15 has emerged as a significant co-modulator of thiopurine therapy....
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