Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients.

doi:10.1093/ibd/izae109

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Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients.

Inflammatory bowel diseases - 5 Dec 2024

Kennedy April M, Griffiths Anne M, Muise Aleixo M, Walters Thomas D, Ricciuto Amanda, Huynh Hien Q, Wine Eytan, Jacobson Kevan, Lawrence Sally, Carman Nicholas, Mack David R, deBruyn Jennifer C, Otley Anthony R, Deslandres Colette, El-Matary Wael, Zachos Mary, Benchimol Eric I, Critch Jeffrey, Schneider Rilla, Crowley Eileen, Li Michael, Warner Neil, McGovern Dermot P B, Li Dalin, Haritunians Talin, Rudin Sarah, Cohn Iris

Abstract excerpt

BACKGROUND: Patients with inflammatory bowel disease (IBD) exhibit considerable interindividual variability in medication response, highlighting the need for precision medicine approaches to optimize and tailor treatment. Pharmacogenetics (PGx) offers the ability to individualize dosing by examining genetic factors underlying the metabolism of medications such as thiopurines. Pharmacogenetic testing can identify...

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PMID: 38788739
DOI: 10.1093/ibd/izae109
PMCID: PMC11630297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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