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Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes

23 Sept 2021

Abstract excerpt

IL-27 controls a diverse range of immune responses in many disease settings. Here, we identify intestinal epithelial cells (IECs) as one of the major IL-27 cellular sources in the gut-associated tissue. Unlike IL-27 secreted by innate immune cells, gut epithelial IL-27 is dispensable for T-bet+ regulatory T cell (T reg cell) differentiation or IL-10 induction. Rather, IEC-derived IL-27 specifically promotes a...

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PMID: 34554189
DOI: 10.1084/jem.20210021

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