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Article

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

3 Jan 2019

Abstract excerpt

Cellular senescence entails a stable cell-cycle arrest and a pro-inflammatory secretory phenotype, which contributes to aging and age-related diseases. Obesity is associated with increased senescent cell burden and neuropsychiatric disorders, including anxiety and depression. To investigate the role of senescence in obesity-related neuropsychiatric dysfunction, we used the INK-ATTAC mouse model, from which p16...

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PMID: 30612898
DOI: 10.1016/j.cmet.2018.12.008

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