Ligand supplementation restores the cancer therapy efficacy of an antirheumatic drug auranofin from serum inactivation

Abstract excerpt

<h4>ABSTRACT</h4> Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion’s dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast formation of covalent albumin-gold adducts. Here we report that newly-added thiols can modulate the dynamic albumin-gold binding and recover the therapeu...

Topics

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• Diet, Metabolism, and Disease
• Gold
• Helicobacter pylori-related gastroenterology studies
• Inflammatory mediators and NSAID effects
• Metal complexes synthesis and properties
• Metal Nanoparticles
• Nanoplatforms for cancer theranostics
• Neoplasms

Identifiers and source

Literature Corpus work

e5fc644e-4ac2-5e3d-a62f-a05738d3fcab

DOI

10.1101/2024.01.25.577173