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The Thiopurine Tale: An Unexpected Journey

11 Jan 2022

Abstract excerpt

Exactly 70 years ago [1951] mercaptopurine was discovered by Gertrude Elion as a novel treatment option for acute leukaemia. A total of three thiopurines (also thioguanine [1950] and azathioprine [1957]) were developed over time. These immunosuppressive drugs were also successfully introduced a few decades later to prevent rejection of transplanted organs and to treat several autoimmune diseases. For her...

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PMID: 35024806
DOI: 10.1093/ecco-jcc/jjac004

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