Development of a chemically modified recombinant α1-antitrypsin mutant expressed in E. coli for therapeutic applications.

Abstract excerpt

Alpha-1-antitrypsin (AAT) is an antiprotease that fulfills a critical physiological function in protecting the lungs from inflammation-induced damage. Inherited AAT deficiency (AATD) represents a clinically significant but often undiagnosed genetic disorder. Native AAT derived from human serum has been utilized as an effective therapeutic agent for treating hereditary emphysema due to AAT deficiency. However, its...

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