Article

Kinetics of Atg2-mediated lipid transfer from the ER can account for phagophore expansion

2020-05-14

Abstract excerpt

The protein Atg2 has been proposed to form a membrane tether that mediates lipid transfer from the ER to the phagophore in autophagy. However, recent kinetic measurements on the human homolog ATG2A indicated a transport rate of only about one lipid per minute, which would be far too slow to deliver the millions of lipids required to form a phagophore on a physiological time scale. Here, we revisit the analysis of...

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Literature Corpus work: 3a7e5344-a281-5b1b-aeb3-cdc9b0b23c3c
DOI: 10.1101/2020.05.12.090977

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