Article
The dynamic Atg13-free conformation of the Atg1 EAT domain is required for phagophore expansion.
Molecular biology of the cell - 15 May 2018
Lin Mary G, Schöneberg Johannes, Davies Christopher W, Ren Xuefeng, Hurley James H
Abstract excerpt
Yeast macroautophagy begins with the de novo formation of a double-membrane phagophore at the preautophagosomal structure/phagophore assembly site (PAS), followed by its expansion into the autophagosome responsible for cargo engulfment. The kinase Atg1 is recruited to the PAS by Atg13 through interactions between the EAT domain of the former and the tMIM motif of the latter. Mass-spectrometry data have shown...
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