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Article

Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation.

Autophagy - 1 Mar 2013

Walczak Marta, Martens Sascha

Abstract excerpt

The activity of the conserved Atg12-Atg5-Atg16 complex is essential for autophagosome formation. However, little is known about its mechanism of action during this process. In our study we employed in vitro systems consisting of purified proteins and giant unilamellar vesicles (GUVs) or small liposomes to investigate membrane binding by the Atg12-Atg5-Atg16 complex and its interplay with the Atg8 conjugation...

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Identifiers

PMID: 23321721
DOI: 10.4161/auto.22931
PMCID: PMC3590266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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