Article

How small molecules stabilize oligomers of a phase-separating disordered protein

2025-11-21

Abstract excerpt

Small molecule inhibitors of the intrinsically disordered androgen receptor activation domain have been tested in clinical trials for the treatment of castration-resistant prostate cancer. These compounds have been shown to stabilize oligomeric forms of the androgen receptor activation domain in solution and alter the properties of androgen receptor condensates. The molecular mechanisms by which small molecules mo...

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Literature Corpus work: 3a791a17-f3ad-5a28-9e6a-fe1cdac8f2bd
DOI: 10.1101/2025.11.20.689623

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