Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancer

31 Dec 2020

Abstract excerpt

Castration resistant prostate cancer (CRPC) continues to be androgen receptor (AR) driven. Inhibition of AR signaling in CRPC could be advanced using state-of-the-art biophysical and biochemical techniques. Structural characterization of AR and its complexes by cryo-electron microscopy would advance the development of N-terminal domain (NTD) and ligand-binding domain (LBD) antagonists. The structural basis of AR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hormonal and reproductive studies
Share to Mass Spectrometry Techniques and Applications
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33384381
DOI: 10.1074/jbc.rev120.012411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancerPMID 33384381Read ↗

Inhibiting androgen receptor splice variants with cysteine-selective irreversible covalent inhibitors to treat prostate cancerSemantic proximity Read ↗

Allosteric interactions prime androgen receptor dimerization and activationSemantic proximity Read ↗

Small Molecules Targeting the Disordered Transactivation Domain of the Androgen Receptor Induce the Formation of Collapsed Helical StatesSemantic proximity Read ↗

Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate CancerSemantic proximity Read ↗

Analyzing the Androgen Receptor Interactome in Prostate Cancer: Implications for Therapeutic InterventionSemantic proximity Read ↗

N-terminal domain of androgen receptor is a major therapeutic barrier and potential pharmacological target for treating castration resistant prostate cancer: a comprehensive reviewSemantic proximity Read ↗

Allosteric interactions prime androgen receptor dimerization and activationSemantic proximity Read ↗

Targeting the BAG-1 family of co-chaperones in lethal prostate cancerSemantic proximity Read ↗

Constitutive activity of the androgen receptor.Semantic proximity Read ↗

A sting in the tail: the N-terminal domain of the androgen receptor as a drug targetSemantic proximity Read ↗

Scaffolds, Sponges, and Steroids: Unraveling the RNA–Kinase Cross-Talk in Advanced Prostate CancerSemantic proximity Read ↗

The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.