Article

TRPC3 suppression ameliorates synaptic dysfunctions and memory deficits in Alzheimer’s disease

2024-09-16

Abstract excerpt

Transient receptor potential canonical (TRPC) channels are widely expressed in the brain; however, their precise roles in neurodegeneration, such as Alzheimer’s disease (AD) remain elusive. Bioinformatic analysis of the published single-cell RNA-seq data collected from AD patient cohorts indicates that the Trpc3 gene is uniquely upregulated in excitatory neurons. TRPC3 expression is also upregulated in post-morte...

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Literature Corpus work: 3a7195aa-39d2-58b1-94e4-25d897f365cd
DOI: 10.1101/2024.09.16.611061

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