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Article

Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs.

Journal of molecular cell biology - 1 Oct 2020

Tao Ran, Lu Rui, Wang Junfeng, Zeng Shujun, Zhang Ting, Guo Wenke, Zhang Xiaobing, Cheng Qi, Yue Chunmei, Wang Yizheng, Jing Naihe

Abstract excerpt

The induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to model and study Alzheimer's disease (AD) under patient-specific genetic background. The lower expression of transient receptor potential canonical 6 (TRPC6) was associated with AD patients, which might be involved in AD pathogenesis. However, the role of TRPC6 that played in AD process still needs more investigation in...

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Identifiers

PMID: 32492143
DOI: 10.1093/jmcb/mjaa027
PMCID: PMC7816687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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