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Article

Antagonistic effects of doublecortin and MARK2/Par-1 in the developing cerebral cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Nov 2008

Sapir Tamar, Shmueli Anat, Levy Talia, Timm Thomas, Elbaum Michael, Mandelkow Eva-Maria, Reiner Orly

Abstract excerpt

Abnormal neuronal migration is manifested in brain malformations such as lissencephaly. The impairment in coordinated cell motility likely reflects a faulty mechanism of cell polarization or coupling between polarization and movement. Here we report on the relationship between the polarity kinase MARK2/Par-1 and its substrate, the well-known lissencephaly-associated gene doublecortin (DCX), during cortical radial...

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Source

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Identifiers

PMID: 19036994
DOI: 10.1523/JNEUROSCI.2363-08.2008
PMCID: PMC6671805

Genes

MARK2
DCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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