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Article

A host-pathogen metabolic synchrony that facilitates disease tolerance

19 Apr 2025

Abstract excerpt

Disease tolerance mitigates organ damage from non-resolving inflammation during persistent infections, yet its underlying mechanisms remain unclear. Here we show, in a Pseudomonas aeruginosa pneumonia mouse model, that disease tolerance depends on the mitochondrial metabolite itaconate, which mediates cooperative host-pathogen interactions. In P. aeruginosa, itaconate modifies key cysteine residues in TCA cycle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40253414
DOI: 10.1038/s41467-025-59134-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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