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Host- and microbial-mediated mucin degradation differentially shape <i>Pseudomonas aeruginosa</i> physiology and gene expression

2025-06-19

Abstract excerpt

Pseudomonas aeruginosa is a hallmark pathogen of cystic fibrosis (CF) airway infections, capable of reaching high cell densities despite its limited ability to directly utilize mucin glycoproteins as a nutrient source. In the CF lung, however, P. aeruginosa may access preferred carbon sources (e.g., amino acids and short-chain fatty acids) through metabolic cross-feeding with co-colonizing mucin-degrading microbe...

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Literature Corpus work
5bad509e-fe5e-513f-8eb5-697dc8ac14bf
DOI
10.1101/2025.06.18.660398
Open publication

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