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Article

Airway immunometabolites fuel Pseudomonas aeruginosa infection

1 Dec 2020

Abstract excerpt

Pulmonary infections are associated with a brisk inflammatory reaction to bacterial surface components. Lipopolysaccharides (LPS) trigger macrophage activation and release of mitochondrial metabolites that control the intensity of the immune response. Whereas succinate induces oxidative stress (ROS), HIF1α stabilization, glycolysis and IL-1β release, itaconate suppresses inflammation by inhibiting succinate...

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PMID: 33302964
DOI: 10.1186/s12931-020-01591-x

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