Article
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature - 17 Aug 2011
Frezza Christian, Zheng Liang, Folger Ori, Rajagopalan Kartik N, MacKenzie Elaine D, Jerby Livnat, Micaroni Massimo, Chaneton Barbara, Adam Julie, Hedley Ann, Kalna Gabriela, Tomlinson Ian P M, Pollard Patrick J, Watson Dave G, Deberardinis Ralph J, Shlomi Tomer, Ruppin Eytan, Gottlieb Eyal
Abstract excerpt
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid cycle (TCA cycle) that catalyses the hydration of fumarate into malate. Germline mutations of FH are responsible for hereditary leiomyomatosis and renal-cell cancer (HLRCC). It has previously been demonstrated that the absence of FH leads to the accumulation of fumarate, which activates hypoxia-inducible factors (HIFs) at normal oxygen tensions....
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